A mathematical model of the effects of acetylcholine pulses on sinoatrial pacemaker activity.
Population
Mathematical model of dynamic vagus-sinus interactions based on Hodgkin and Huxley-type equations
Design
Preclinical
Authors
Discussion
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Member takes
Overview
May explain vagally mediated sinus arrhythmias including paradoxical acceleration; leaves open clinical translation from this Level 5 model.
Structured PICO
P
Population
Mathematical model of dynamic vagus-sinus interactions based on Hodgkin and Huxley-type equations
I
Intervention
Simulated brief vagal pulses using a concentration-dependent, acetylcholine-activated, potassium current
O
Outcome
Changes in pacemaker rhythm (phase-response curves and synchronization patterns)surrogate
A mathematical model of vagus-sinus interactions successfully simulates complex arrhythmic patterns and paradoxical acceleration, providing a theoretical basis for clinically observed sinus rhythm disturbances.
Cite This Study
Michaels et al. (1984) studied this question.