Mathematical model of the changes in heart rate elicited by vagal stimulation.
Population
Mathematical model of a pacemaker cell with six membrane ionic currents simulating intact animals
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Informs computational models of vagal sinus node control; leaves open translation beyond animal preparations.
Structured PICO
P
Population
Mathematical model of a pacemaker cell with six membrane ionic currents simulating intact animals
I
Intervention
Simulated vagal stimulation
O
Outcome
Changes in sinus cycle length (SCL)surrogate
A mathematical model demonstrates that sinus cycle length increases linearly with vagal stimulation frequency due to ACh saturation and geometric SCL response.
Cite This Study
Dexter et al. (1989) studied this question.