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June 3, 2026The Journal of Organic Chemistry

Photoinduced Cyclization of 2-Alkynylanilines to Access 3-Bromoindole Scaffolds

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Authors

LCL ChenBeijing Institute of TechnologyLLLuomo LiBeijing Institute of TechnologyYCYuehua ChenBGI Group (China)

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Implication

Randomized trial demonstrates efficient 3-bromoindole synthesis in a simple, one-step process, highlighting its practical utility.

Key Points

  • The aim is to develop a new method for synthesizing 3-bromoindoles efficiently using visible light.
  • Developed a photocatalyst-free protocol using visible light for synthesis.
  • Utilized 2-alkynylanilines and ethyl 2,2-dibromo-3-oxobutanoate as starting materials.
  • Conducted mechanistic studies to analyze the radical pathway of the reaction.
  • Successfully synthesized 3-bromoindoles with excellent functional group tolerance.
  • Demonstrated scalability with gram-scale synthesis of the desired product.
  • Mechanistic studies revealed homolytic cleavage initiated by visible light.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc44edee9eb8c0dce5e01https://doi.org/10.1021/acs.joc.6c00911
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