Key result
Nocturnal hypertension in CKD links to ~29% higher nighttime sodium excretion and more frequent nocturia.
Why the study?
Higher nighttime natriuresis is linked to elevated nighttime BP in the general population, but detailed evidence in CKD patients is scarce.
Does increased nighttime urine sodium excretion correlate with nocturnal hypertension and nocturia in patients with chronic kidney disease?
Population
130 patients with CKD stages 1–5 on stable antihypertensive treatment
Comparison
Tertiles of nighttime-to-daytime urine sodium excretion ratio and presence vs absence of nocturnal hypertension
Design
Cross-sectional study
Follow-up
24-h
Authors
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Does not support practice changes in CKD; leaves open whether targeting nighttime natriuresis improves BP control or outcomes.
Cross-Sectional (n=130)
Does increased nighttime urine sodium excretion correlate with nocturnal hypertension and nocturia in patients with chronic kidney disease?
Absolute Event Rate: 64% vs 49.7%
p-value: p=0.012
In patients with CKD, increased nighttime natriuresis is significantly associated with higher nighttime blood pressure and nocturnal hypertension, independent of total sodium excretion.
Karagiannidis et al. (2026) conducted a cross-sectional in Chronic kidney disease (n=130). Nocturnal hypertension vs. Without nocturnal hypertension was evaluated on Nighttime urine sodium excretion (mEq) (p=0.012). In patients with CKD, nocturnal hypertension was associated with significantly higher nighttime urine sodium excretion (64.0 vs 49.7 mEq, P=0.012) and more frequent nocturia.
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