Outcomes and Tolerability of Office-Based Endoscopic Polypectomy for Chronic Rhinosinusitis with Nasal Polyps: A Prospective Study

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by bilateral and multifocal polyps and has been shown to decrease health-related quality of life (HRQOL). Standard treatment includes steroids and endoscopic sinus surgery. Office-based endoscopic polypectomy has become increasingly popular in recent years. This study aimed to evaluate the outcomes and tolerability of office-based endoscopic polypectomy using a microdebrider under local anesthesia. This prospective observational study enrolled 19 patients with CRSwNP, according to the EPOS2020 criteria. All patients underwent office-based endoscopic polypectomy. Efficacy of treatment was assessed using the SNOT-22 questionnaire three and six months postoperatively. The perioperative experiences of patients and surgeons were evaluated using questionnaires. The mean SNOT-22 score decreased from 59.7 (SD 21.8) to a mean of 37.1 (SD 26.6 p < 0.001) after three months, and was maintained at 6 months, with a mean of 35.2 (SD 17.6 p < 0.001). The majority reported good comfort levels and did not prefer performing the procedure in an operating room under general anesthesia. The results show that office-based endoscopic polypectomy under local anesthesia is an effective method for relieving symptoms (SNOT-22) and is well-tolerated. The effect was maintained after six months.