What does this research mean for the field?

In patients with glomerular diseases, hypertension phenotypes identified by ambulatory blood pressure monitoring correlate with chronic kidney disease stage and exhibit distinct renin-angiotensin-aldosterone system activity patterns, with the aldosterone component predominating in uncontrolled hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This research aims to explore the variability of hypertension phenotypes and RAAS activity in patients with glomerular diseases.

June 3, 2026Journal of Hypertension0 citations

Ambulatory Blood Pressure Phenotypes and RAAS Activity in Glomerular Disease Patients

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Chronic glomerulonephritis (n=61). Intervention: Hypertension phenotypes identified by ambulatory blood pressure monitoring. Primary outcome: RAAS activity (plasma aldosterone, plasma renin activity, and aldosterone to renin ratio).

Ambulatory Blood Pressure Phenotypes and Raas Activity in Patients With Glomerular Diseases

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Population

61 patients with chronic glomerulonephritis, median age 55 years, 60% male. Key inclusion: all patients were…

Design

Cohort

Key result

Ambulatory blood pressure monitoring identified uncontrolled hypertension in 39.3% of patients with glomerular diseases, a phenotype associated with the highest aldosterone-to-renin ratios.

Authors

BKBibisoro Komilova KDKsenia Demyanova NKN. L. Kozlovskaya

Discussion

Member takes

Overview

ABPM may aid detection of high-risk phenotypes in glomerular disease; leaves open whether RAAS modulation improves control.

Key Points

This research aims to explore the variability of hypertension phenotypes and RAAS activity in patients with glomerular diseases.
Cohort single center observational study included 61 patients with chronic glomerulonephritis.
Blood pressure measured using ambulatory blood pressure monitoring and office BP.
RAAS activity assessed in 44 patients through plasma aldosterone and plasma renin activity measurements.
24 patients (39.3%) had uncontrolled hypertension based on ABPM results.
Significant variations in RAAS activity observed across hypertension phenotypes, particularly in uncontrolled hypertension group.
No significant differences in aldosterone levels, but the aldosterone to renin ratio was highest in the uncontrolled hypertension group.

Study Design

Type

Cohort (n=61)

Multicenter

Structured PICO

Population

61 patients (median age 55 years, 40% female) with chronic glomerulonephritis on combination antihypertensive therapy.

Exposure

Ambulatory blood pressure monitoring (ABPM) and renin-angiotensin-aldosterone system (RAAS) assessment (plasma aldosterone, plasma renin activity, and aldosterone to renin ratio)

Outcome

Hypertension phenotypes based on ABPM and their association with RAAS activitysurrogate

ABPM and RAAS assessment in patients with glomerular diseases reveal distinct hypertension phenotypes with varying RAAS activity, highlighting the importance of ABPM for guiding antihypertensive therapy.

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Cite This Study

Komilova et al. (2026) conducted a cohort in Chronic glomerulonephritis (n=61). Hypertension phenotypes identified by ambulatory blood pressure monitoring was evaluated on RAAS activity (plasma aldosterone, plasma renin activity, and aldosterone to renin ratio). Ambulatory blood pressure monitoring identified uncontrolled hypertension in 39.3% of patients with glomerular diseases, a phenotype associated with the highest aldosterone-to-renin ratios.

synapsesocial.com/papers/6a1fc530dee9eb8c0dce6a5a https://doi.org/10.1097/01.hjh.0001196100.71159.bc

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June 3, 2026Journal of Hypertension0 citations

Ambulatory Blood Pressure Phenotypes and RAAS Activity in Glomerular Disease Patients

Ambulatory Blood Pressure Phenotypes and Raas Activity in Patients With Glomerular Diseases

View Full Paper

Population

61 patients with chronic glomerulonephritis, median age 55 years, 60% male. Key inclusion: all patients were…

Design

Cohort

Key result

Ambulatory blood pressure monitoring identified uncontrolled hypertension in 39.3% of patients with glomerular diseases, a phenotype associated with the highest aldosterone-to-renin ratios.

Authors

BKBibisoro Komilova KDKsenia Demyanova NKN. L. Kozlovskaya

Discussion

Member takes

Overview

ABPM may aid detection of high-risk phenotypes in glomerular disease; leaves open whether RAAS modulation improves control.

Key Points

This research aims to explore the variability of hypertension phenotypes and RAAS activity in patients with glomerular diseases.
Cohort single center observational study included 61 patients with chronic glomerulonephritis.
Blood pressure measured using ambulatory blood pressure monitoring and office BP.
RAAS activity assessed in 44 patients through plasma aldosterone and plasma renin activity measurements.
24 patients (39.3%) had uncontrolled hypertension based on ABPM results.
Significant variations in RAAS activity observed across hypertension phenotypes, particularly in uncontrolled hypertension group.
No significant differences in aldosterone levels, but the aldosterone to renin ratio was highest in the uncontrolled hypertension group.

Study Design

Type

Cohort (n=61)

Multicenter

Structured PICO

Population

61 patients (median age 55 years, 40% female) with chronic glomerulonephritis on combination antihypertensive therapy.

Exposure

Ambulatory blood pressure monitoring (ABPM) and renin-angiotensin-aldosterone system (RAAS) assessment (plasma aldosterone, plasma renin activity, and aldosterone to renin ratio)

Outcome

Hypertension phenotypes based on ABPM and their association with RAAS activitysurrogate

Ask AI

Helpful

Bookmark

View Full Paper

Cite This Study

synapsesocial.com/papers/6a1fc530dee9eb8c0dce6a5a https://doi.org/10.1097/01.hjh.0001196100.71159.bc

Ask AI

Helpful

Bookmark

View Full Paper