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June 3, 2026Annals of General PsychiatryOpen Access

Efficacy and safety of repetitive transcranial magnetic stimulation in anorexia and bulimia nervosa: a systematic review and meta-analysis

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Authors

DEDalia Kamal EwisHSHaneen SabetYHYousef Hawas

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Overview

Systematic review evaluates rTMS effects on psychological outcomes in anorexia and bulimia nervosa, suggesting potential benefits.

Key Points

  • This meta-analysis aimed to assess the efficacy and safety of rTMS in treating anorexia nervosa and bulimia nervosa.
  • Conducted comprehensive literature search from multiple databases up to May 2025.
  • Included 13 clinical trials with 195 active rTMS and 132 sham treatments.
  • Data pooled using fixed or random-effects models, calculating mean differences and assessing risk of bias.
  • No significant change in BMI for anorexia nervosa patients (MD: 0.19, 95% CI: -0.50, 0.88, P=0.59).
  • Moderate reduction in eating disorder severity (SMD: -0.50, 95% CI: -0.90 to -0.10, p=0.01).
  • Depression symptoms improved with rTMS (SMD: -0.41, 95% CI: -0.81 to -0.02, p=0.04), while anxiety and other behavioral symptoms did not.

Cite This Study

Ewis et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc56bdee9eb8c0dce6d7ahttps://doi.org/10.1186/s12991-026-00673-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcranial Direct Current Stimulation in Anorexia Nervosa: A Randomized Sham-Controlled Trial2026
  2. 2Effects of repetitive transcranial magnetic stimulation of the right inferior parietal lobe on the body image perception in anorexia nervosa: A pilot randomized controlled study2024 · 6 citations
  3. 3The efficacy of transcranial direct current stimulation in the treatment of anorexia nervosa: a randomized double-blind clinical trial2024 · 5 citations
  4. 4Repetitive Transcranial Magnetic Stimulation ( rTMS ) for Adolescent Depression: A Systematic Review and Meta‐Analysis of Treatment Response and Suicidal Ideation Reduction2026
  5. 5Cognitive Behavioral Therapy Reduces Symptom Severity and Normalizes Neurophysiological and Attentional Reactivity in Anorexia Nervosa: A Randomized Controlled Trial2026