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June 3, 2026Acta EpileptologicaOpen Access

Long-term effects of carbamazepine on bone-related biochemical markers in patients with epilepsy

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This study evaluates the long-term effects of carbamazepine on bone-related biochemical markers in patients with epilepsy.
Observed 226 patients treated with carbamazepine at King Abdulaziz Medical City, Saudi Arabia.
Measured pre- and post-treatment serum levels of vitamin D, alkaline phosphatase, calcium, and sodium.
Utilized statistical analysis for significant changes in biochemical markers.
Significant decrease in vitamin D levels after treatment (mean ± SD= 36.6 ± 15.68 nmol/L; p=0.007).
Calcium levels significantly reduced post-treatment (p < 0.001).
Sodium levels also significantly decreased (p = 0.019), while alkaline phosphatase showed no significant change.

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Observational study assesses biochemical markers related to bone health in epilepsy patients using carbamazepine, indicating potential risks.

Hakami et al. (2026) studied this question.

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Observational study assesses biochemical markers related to bone health in epilepsy patients using carbamazepine, indicating potential risks.