The Triglyceride Glucose Chinese Visceral Adiposity Index, a Novel Marker Integrating Lipid Metabolism and Visceral Adiposity, Is Associated With New-Onset Hypertension in Middle-A

Objective: The TyG index and the CVAI are recognized markers of insulin resistance and visceral adiposity, respectively. However, the association of their product, the TyG-CVAI index, with the risk of new-onset hypertension remains unclear.Design and method: This prospective analysis included 6,516 participants from the CHARLS study without baseline hypertension. Participants were categorized into TyG-CVAI tertiles (T1-T3). The primary outcome was new-onset hypertension incidence, analyzed using Cox proportional hazards models to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During the follow-up period from 2013 to 2020, 1517 incident hypertension cases were documented. A significant positive association was observed between TyG-CVAI indices and hypertension risk. In fully adjusted models, participants in the highest tertile of baseline TyG-CVAI had a 93% increased hypertension risk compared to the lowest tertile. The highest cumulative TyG-CVAI tertile was associated with an 89% risk elevation. Restricted cubic splines revealed a nonlinear relationship, and Kaplan-Meier curves showed significant divergence in cumulative hypertension incidence among the tertiles (Log-rank P <0.001). Furthermore, the TyG-CVAI index demonstrated superior predictive performance for hypertension incidence compared to its individual components. Conclusions: A higher cumulative TyG-CVAI index is independently and positively associated with an increased risk of new-onset hypertension in the Chinese population. This composite index may serve as a valuable, simple, and cost-effective tool for the early identification of individuals at high risk for hypertension, facilitating targeted preventive strategies.