Managing Hypertension Among People Living With Hiv: An Integrated Model Trial

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Uncontrolled hypertension in people living with HIV (n=954). Intervention: Task-Strengthening Strategy for Hypertension control (TASSH) plus practice facilitation (PF) vs. Self-directed care (TASSH alone). Primary outcome: Systolic blood pressure (SBP) reduction (MD -2.7 mmHg, 95% CI -4.53 to -0.85, p=0.004).

Q: What does this research mean for the field?

Integrating the Task-Strengthening Strategy for Hypertension control (TASSH) using practice facilitation significantly reduces systolic blood pressure and achieves high blood pressure control rates among people living with HIV compared to self-directed care. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Dike Ojji; Angela Aifah; Erinn Hade; Weixi Chen; Anyiekere Ekanem; Daniel Henry; Shivani Mishra; Nafesa Kanneh; Deborah Onakomaiya; Saviour Emmanuel; Esther Okon; Dorcas Ekpoudom; Ifiok Itun; Samuel Osagie; Anthony Orji; Adeola Adedokun; Daphne Lew; Angela Attah; Juliet Iwelunmor; Olugbenga Ogedegbe

doi:10.1097/01.hjh.0001197528.70383.35

Why the study?

The comparative effectiveness of practice facilitation versus self-directed care for integrating the Task-Strengthening Strategy for Hypertension control into HIV chronic care platforms was unestablished.

Does practice facilitation added to a task-strengthening strategy improve systolic blood pressure reduction and BP control in people living with HIV with uncontrolled hypertension?

Key Points

To compare the effectiveness of practice facilitation versus self-directed care for hypertension management in HIV care.
Stepped-wedge cluster randomised trial across 30 primary healthcare centers in Nigeria.
Participants included 954 individuals living with HIV and uncontrolled hypertension, enrolled from 2022 to 2023.
Interventions included an adaptation of the TASSH strategy with either practice facilitation or self-directed care.
BP control improved from 85.3% to 90.6% during the intervention (P=0.06).
Practice facilitation reduced systolic blood pressure by 2.7 mmHg compared to self-directed care (P=0.004).
SBP decreased from 152.6 mmHg at baseline to 123.5 mmHg after 12 months of intervention.

Study Design

Type

RCT (n=954)

Randomization

stepped-wedge cluster

Multicenter

Yes

Structured PICO

Does practice facilitation added to a task-strengthening strategy improve systolic blood pressure reduction and BP control in people living with HIV with uncontrolled hypertension?

P

Population

954 people living with HIV with uncontrolled hypertension across 30 primary healthcare centers in Nigeria, followed for 12 months.

I

Intervention

Practice facilitation (PF) added to Task-Strengthening Strategy for Hypertension control (TASSH) for 12 months.

C

Comparator

Self-directed care (SDC) consisting of TASSH alone.

O

Outcome

Difference in systolic blood pressure (SBP) reduction and BP control (<140/90mmHg) at 12 months.surrogate

Main Result

Mean Difference: -2.7 (95% CI -4.53–-0.85)

p-value: p=0.004

Implication

Using practice facilitation as an implementation strategy to integrate hypertension management into HIV care significantly reduced systolic blood pressure compared to self-directed care.

Discussion

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Cite This Study

Ojji et al. (2026) conducted an RCT in Uncontrolled hypertension in people living with HIV (n=954). Task-Strengthening Strategy for Hypertension control (TASSH) plus practice facilitation (PF) vs. Self-directed care (TASSH alone) was evaluated on Systolic blood pressure (SBP) reduction (MD -2.7 mmHg, 95% CI -4.53 to -0.85, p=0.004).

synapsesocial.com/papers/6a1fc58bdee9eb8c0dce6f58 https://doi.org/10.1097/01.hjh.0001197528.70383.35

Topics

Hypertension management

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Managing Hypertension Among People Living With Hiv: An Integrated Model Trial

Key Points

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

Topics

Managing Hypertension Among People Living With Hiv: An Integrated Model Trial

Key Points

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

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Topics

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