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June 3, 2026Journal of Hypertension0 citations

Primary Non-Adherence to Antihypertensive Medication After Intensification

Primary Non-Adherence After Intensification of Antihypertensive Medication: The Path Study

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Why the study?

Does non-adherence to a new antihypertensive prescription affect blood pressure control at 4 months in adult patients with uncontrolled hypertension?

Population

207 adult patients with a documented history of hypertension and an office BP >=140/90 mmHg, median age 70…

Comparison

New prescription for antihypertensive medication vs Patients without therapy intensification, or…

Design

Cohort

Follow-up

4 months

Key result

Primary non-adherence occurred in 8% (95% CI 4-14%) of patients receiving a new antihypertensive prescription, and systolic BP reduction did not differ significantly based on adherence (p=0.19).

Authors

KSKari SavilleVZVictor ZeijenATAn Tran

Discussion

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Overview

Non-adherence to new antihypertensives may not limit early BP control; leaves open whether targeted interventions improve outcomes in larger cohorts.

Key Points

  • This study aims to assess the rate of primary non-adherence to antihypertensive medications and its association with blood pressure control.
  • Single-center, prospective cohort study
  • Included 207 adult patients with a history of hypertension and baseline BP >=140/90 mmHg
  • Primary non-adherence defined as lack of prescription dispensing within 30 days.
  • Primary non-adherence observed in 10 patients (8%; 95% CI: 4–14%)
  • Early non-adherence found in 31 patients (24%; 95% CI: 17–33%)
  • At 4 months, BP control achieved in 67 patients (35%; 95% CI: 28–43%).

Study Design

Type

Cohort (n=207)

Multicenter

No

Structured PICO

Does non-adherence to a new antihypertensive prescription affect blood pressure control at 4 months in adult patients with uncontrolled hypertension?

P
Population
207 adult patients with a documented history of hypertension and an office BP >=140/90 mmHg, followed for 4 months.
E
Exposure
New prescription for antihypertensive medication (therapy intensification)
C
Comparator
Patients without therapy intensification, or patients adherent to their new prescription
O
Outcome
Rate of primary non-adherence (not dispensing prescription within 30 days) and association of non-adherence with blood pressure control at 4 monthssurrogate

Primary non-adherence to newly prescribed antihypertensive medications occurs in 8% of patients, increasing to 24% by 4 months, highlighting a significant barrier to effective hypertension management.

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Cite This Study

Saville et al. (2026) conducted a cohort in Hypertension (n=207). New prescription for antihypertensive medication was evaluated on Primary non-adherence (not dispensing a prescription within 30 days) (95% CI 4-14). Primary non-adherence occurred in 8% (95% CI 4-14%) of patients receiving a new antihypertensive prescription, and systolic BP reduction did not differ significantly based on adherence (p=0.19).

synapsesocial.com/papers/6a1fc6cddee9eb8c0dce7bd3https://doi.org/10.1097/01.hjh.0001195096.66023.18
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