Hybrid perfusion-diffusion PBK model predicts organ-specific nano- and microplastic distributions in humans, suggesting distinct exposure profiles.
• Probabilistic PBK model captures polydisperse NMP kinetics. • Transport shifts smoothly from perfusion to diffusion with particle size. • Model predicts organ-specific particle numbers and size distributions. • Mouse-calibrated model scales to human inhalation and ingestion exposure. • Inhalation and ingestion show distinct, feces-dominated kinetic profiles.
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Wardani et al. (2026) studied this question.
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