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The review aims to summarize the effects of beta-blockers on memory performance based on randomized controlled trials.

Impact of Beta Blockers on Memory: Systematic Review of Neuropsychological Findings

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The review aims to summarize the effects of beta-blockers on memory performance based on randomized controlled trials.
Conducted a systematic literature search in PubMed for relevant double-blind randomized controlled trials.
Included 59 studies with 2,565 participants assessing the cognitive effects of beta-blockers using standardized neuropsychological tests.
Analyzed different memory tasks including verbal, figural, emotional, and stress-related paradigms.
Significant effects on memory performance were reported in 33 studies, predominantly in single-dose conditions.
Heterogeneous findings indicate that memory tasks related to emotional content were more sensitive to beta-adrenergic modulation than neutral tasks.
Long-term beta-blocker exposure was generally not associated with clinically meaningful changes in memory function.

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Systematic review investigates beta-blockers affecting memory functions in humans, suggesting context-dependent impacts.

Wloka et al. (2026) studied this question.

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