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June 3, 2026Bone ResearchOpen Access

Exploring mitochondrial functions and dysfunctions in chondrocytes: toward the identification of novel therapies for osteoarthritis

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Authors

LDLucie DanetInsermJGJérôme GuicheuxInsermMBMarie‐Astrid BoutetInserm

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Implication

Narrative review examines mitochondrial roles in chondrocytes, suggesting novel therapies for osteoarthritis.

Key Points

  • This review explores mitochondrial functions and dysfunctions in chondrocytes, particularly related to osteoarthritis (OA).
  • Examined literature on mitochondrial roles in chondrocytes and their dysregulation in OA.
  • Investigated structural and functional alterations in mitochondria associated with OA pathology.
  • Discussed therapeutic strategies targeting mitochondrial dysfunctions in OA.
  • Mitochondrial dysfunctions are linked to the dysregulation of energy metabolism in OA chondrocytes.
  • Potential therapeutic strategies targeting mitochondrial functions show promise for developing new disease-modifying drugs for OA.
  • Current understanding indicates that both structural and functional mitochondrial alterations contribute significantly to OA pathology.

Cite This Study

Danet et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc76ddee9eb8c0dce8435https://doi.org/10.1038/s41413-026-00548-y
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