Diastolic blood pressure variability was negatively correlated with frailty assessed by the Clinical Frailty Score (r=-0.2, p=0.03) and Fried's Frailty Phenotype (r=-0.3, p=0.01).
Cohort (n=100)
Is ambulatory blood pressure variability associated with frailty in community-dwelling older adults?
Diastolic, but not systolic, ambulatory blood pressure variability is negatively correlated with frailty assessed by the Clinical Frailty Score and Fried's Frailty Phenotype in community-dwelling older adults.
Effect estimate: r=-0.3
p-value: p=0.01
Objective: The relationship between frailty and cardiovascular disease is well established. Blood pressure variability is also an established risk factor for cardiovascular events, and it has been shown to be associated with ageing. The association between ambulatory blood pressure (ABP) variability with frailty was explored. Design and method: One hundred community-dwelling adults were recruited into the longitudinal cardiovascular Frailty (c-FRAIL) study. Frailty assessments were done using the Clinical Frailty Score (CFS), Fried's Frailty Phenotype (FP), Short Physical Performance Battery (SPPB) and PRISMA-7. Participants were categorised as robust or frail based on cut-offs specified by each assessment tool. Ambulatory blood pressure measurements were taken over 24 hours for 94 study participants, using the DIASYS-3 PLUS (Novacor®). Results: The median age at baseline was 74 (range 65-101) years, with 50% male. Systolic blood pressure variability (SBPV) and diastolic blood pressure variability (DBPV) were calculated using the standard deviation (SD) and co-efficient of variation (CoV). CFS and FP were negatively correlated with DBPV (SD DBP r= -0.2, p=0.03 and r=-0.3, p=0.01; CoVDBP r=-0.2, p=0.05 and r=-0.2, p=0.02 respectively) but not with SBP (SD SBP r= -0.1; p=0.2 and r= -0.2; p=0.1; CoVSBP r=-0.2; p=0.06 and r=-0.2, p=0.1 respectively). No significant correlations were found between measures of blood pressure variability with SPPB or PRISMA-7. Conclusions: Frailty, assessed by CFS and FP, was associated with DBPV and not SBPV. Non-invasive DBPV assessment therefore holds the potential to be a useful tool in evaluating frailty.
Mensah et al. (Fri,) conducted a cohort in Frailty (n=100). Ambulatory blood pressure variability was evaluated on Correlation between frailty scores (CFS and FP) and diastolic blood pressure variability (r=-0.3, p=0.01). Diastolic blood pressure variability was negatively correlated with frailty assessed by the Clinical Frailty Score (r=-0.2, p=0.03) and Fried's Frailty Phenotype (r=-0.3, p=0.01).