Key result
PMAxx pretreatment eliminates heat-inactivated HAV RT-qPCR signals by ~4 logs, helping discriminate infectious foodborne viruses.
PMAxx pretreatment shows potential to discriminate between infectious and non-infectious foodborne viruses by RT-qPCR, though its efficacy varies by inactivation method and requires dilution in food matrices.
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Hypothesis-generating for PMAxx in distinguishing infectious HAV; validation needed across inactivation methods and matrices.
Lauzier et al. (2025) studied Foodborne viruses (HAV, HuNoV). Sample pretreatments (PMAxx, magnetic silica beads, centrifugal filter) vs. No pretreatment / virions without food matrix was evaluated on RT-qPCR signal reduction of inactivated viruses. PMAxx pretreatment eliminated the RT-qPCR signal of heat-inactivated HAV (3.96 ± 1.24 log gc reduction), showing potential to discriminate infectious from non-infectious foodborne viruses.
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