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January 1, 2010Open Access

Fibroblast Growth Factor 2 Mediates Isoproterenol-induced Cardiac Hypertrophy through Activation of the Extracellular Regulated Kinase.

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Population

Wildtype, Fgf2 knockout, non-transgenic, and FGF2 transgenic mice

Comparison

Isoproterenol via subcutaneous mini-osmotic pump… vs Saline via subcutaneous mini-osmotic pump implants

Design

Preclinical

Authors

SHStacey L. HouseWashington University in St. LouisBHBrian E. HouseUniversity of CincinnatiBGBetty J. GlascockCincinnati Children's Hospital Medical Center

Discussion

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Overview

FGF2-ERK inhibition may mitigate stress-induced hypertrophy; leaves open clinical translation beyond rodent models.

Structured PICO

P
Population
Wildtype, Fgf2 knockout, non-transgenic, and FGF2 transgenic mice
I
Intervention
Isoproterenol via subcutaneous mini-osmotic pump implants (with or without pharmacologic inhibition of ERK or p38)
C
Comparator
Saline via subcutaneous mini-osmotic pump implants
O
Outcome
Cardiac hypertrophy assessed by heart weight-to-body weight ratios and myocyte cross-sectional areasurrogate

FGF2 mediates isoproterenol-induced cardiac hypertrophy and maladaptive dysfunction through the activation of the ERK signaling pathway.

Cite This Study

House et al. (2010) studied this question.

synapsesocial.com/papers/6a1fc85c19f879035ebb41fdhttps://doi.org/10.4255/mcpharmacol.10.20
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Also Consider

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  1. 1G protein‐coupled receptor signalling in in vivo cardiac overload2001 · 9 citations
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  3. 3c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells2002 · 157 citations
  4. 4Fibroblast Growth Factor in the Extracellular Matrix of Dystrophic (mdx) Mouse Muscle1989 · 267 citations
  5. 5A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway1997 · 881 citations