Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization

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PDE1C overexpression contributes to paclitaxel resistance, and phosphodiesterase 1 inhibitors enhance paclitaxel cytotoxicity by promoting microtubule stabilization. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Hsiao‐Hui Kuo; Chien‐Wei Huang; Tsai-Ming Lu; Wei-Rou Chiang; Ling‐Huei Yih

doi:10.1016/j.bbadva.2026.100187

January 1, 2026BBA AdvancesOpen Access

Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization

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Abstract

findings indicate that PDE1C overexpression contributes to paclitaxel resistance.

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Kuo et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc9572be0c1f4e3bb4313 https://doi.org/10.1016/j.bbadva.2026.100187

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Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization

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Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization

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