Key result
Cyclic voltammetry enables predictable cTnI detection via a ~95% power-law relationship with interaction rates.
The study demonstrates a predictable concentration-dependent detection model for cardiac troponin I using cyclic voltammetry, which could inform future biosensor development.
Supports aptamer-based cTnI detection models; leaves open clinical biosensor translation pending validation.
In this study, we present a kinetic investigation of interfacial cardiac troponin I (cTnI)-aptamer interactions using cyclic voltammetry (CV). An aptamer-complementary strand complex immobilized on a gold electrode was employed as a model system to examine the concentration-dependent adsorption behavior of cTnI. CV measurements with respect to the interaction time revealed that the interaction process follows pseudo-first-order kinetics under constant surface coverage conditions. By correlating charge variation with fractional surface occupation, an interaction rate constant (k) was derived from the kinetic model. A strong power-law relationship (R² = 0.9515) between cTnI concentration and the derived rate constant was established, demonstrating a predictable concentration-dependent detection.
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Jung et al. (2026) studied Cardiac troponin I detection. Aptamer-complementary strand complex immobilized on a gold electrode was evaluated on Interaction rate constant (k) and concentration-dependent adsorption behavior (R² = 0.9515). Cyclic voltammetry revealed a strong power-law relationship (R² = 0.9515) between cardiac troponin I concentration and the derived interaction rate constant, enabling predictable detection.
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