Key result
Cardiac myosin binding protein-C and its N-terminal fragment C0C1f may serve as early biomarkers of myocardial infarction and contribute to post-MI pathogenesis and cardiac dysfunction.
Design
Review
Authors
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Does not yet support clinical adoption of cMyBP-C fragments for MI; leaves open prospective validation of diagnostic and pathogenic roles.
This review highlights the potential of the cMyBP-C fragment C0C1f as a novel, early biomarker for myocardial infarction and its pathogenic role in post-MI heart failure.
Lynch et al. (2014) conducted a review in Myocardial infarction. Cardiac myosin binding protein-C (cMyBP-C) was evaluated. Cardiac myosin binding protein-C and its N-terminal fragment C0C1f may serve as early biomarkers of myocardial infarction and contribute to post-MI pathogenesis and cardiac dysfunction.
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