Key result
In patients with non-ischemic cardiomyopathy, mid-wall fibrosis was associated with reduced global circumferential strain (-6.6% vs -9.4%, p=0.004) and increased rigid left ventricular body rotation.
Why the study?
Does the presence of left ventricular mid-wall fibrosis impair LV myocardial mechanics in patients with non-ischemic cardiomyopathy?
Cross-Sectional (n=116)
Blinded observers
Yes
Does the presence of left ventricular mid-wall fibrosis impair LV myocardial mechanics in patients with non-ischemic cardiomyopathy?
Absolute Event Rate: -6.6% vs -9.4%
p-value: p=0.004
In patients with non-ischemic cardiomyopathy, mid-wall fibrosis is associated with significant impairments in systolic and diastolic myocardial mechanics despite similar ejection fractions, providing a mechanistic explanation for their higher risk of pump failure.
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May explain excess pump failure risk via impaired mechanics; hypothesis-generating for fibrosis-targeted therapies.
Taylor et al. (2016) conducted a cross-sectional in Non-ischemic cardiomyopathy (n=116). Left ventricular mid-wall fibrosis vs. Absence of mid-wall fibrosis was evaluated on Global circumferential strain (p=0.004). In patients with non-ischemic cardiomyopathy, mid-wall fibrosis was associated with reduced global circumferential strain (-6.6% vs -9.4%, p=0.004) and increased rigid left ventricular body rotation.
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