Key result
Ventricular twist was conserved among mice, rats, and men, leading to significantly smaller torsion but larger circumferential strain and normalized radial shortening in men.
Population
6 male human volunteers, 6 Fischer 344 rats, and 7 C57BL/6 mice
Comparison
Magnetic resonance imaging vs Cross-species comparison
Design
Preclinical
Authors
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Requires caution extrapolating rodent cardiac mechanics to humans; leaves open species-specific validation for translational modeling.
Observational (n=19)
While ventricular twist is conserved across mice, rats, and humans, significant quantitative differences exist in torsion, circumferential strain, and radial shortening, highlighting the need for caution when extrapolating cardiac mechanics data from animals to humans.
Liu et al. (2006) reported an observational. Species differences (mice, rats, men) vs. Cross-species comparison was evaluated on Ventricular wall motion indexes (twist, torsion, circumferential strain, radial shortening). Ventricular twist was conserved among mice, rats, and men, leading to significantly smaller torsion but larger circumferential strain and normalized radial shortening in men.
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