Key result
Conversion to nocturnal home hemodialysis significantly lowered 24-hour mean arterial pressure from 102 to 90 mm Hg (P=0.01) and improved endothelium-dependent vasodilation.
Why the study?
Does nocturnal hemodialysis improve ambulatory blood pressure, peripheral vasodilation, and plasma norepinephrine in patients on conventional hemodialysis?
Observational (n=18)
Does nocturnal hemodialysis improve ambulatory blood pressure, peripheral vasodilation, and plasma norepinephrine in patients on conventional hemodialysis?
Absolute Event Rate: 90% vs 102%
p-value: p=0.01
Conversion from conventional to nocturnal hemodialysis rapidly improves blood pressure, peripheral resistance, sympathetic tone, and endothelial function within 2 months.
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May lower ambulatory BP and improve endothelial function in hemodialysis; hypothesis-generating, requires randomized confirmation before practice change.
Chan et al. (2003) conducted an observational in Hemodialysis (n=18). Nocturnal home hemodialysis vs. Conventional hemodialysis (three 4-hour sessions per week) was evaluated on 24-hour mean arterial pressure (p=0.01). Conversion to nocturnal home hemodialysis significantly lowered 24-hour mean arterial pressure from 102 to 90 mm Hg (P=0.01) and improved endothelium-dependent vasodilation.
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