Key result
In critically ill patients, plasma BNP concentrations were significantly higher in those with cardiac abnormalities (518 vs 60 pg/mL, P<0.001), and independently increased with age and female gender.
Why the study?
Do age, gender, serum creatinine, and electrolyte concentrations confound plasma BNP concentrations in critically ill patients?
Cross-Sectional (n=121)
No
Do age, gender, serum creatinine, and electrolyte concentrations confound plasma BNP concentrations in critically ill patients?
Plasma BNP concentrations in critically ill patients are strongly driven by cardiac abnormalities, but age and gender also contribute significantly and should be considered during interpretation.
Answers are grounded in this paper and cite their sources.
Age/gender adjustment may refine BNP interpretation in critical illness; leaves open optimal thresholds for prospective validation.
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McLean et al. (2003) conducted a cross-sectional in Critically ill (n=121). Cardiac abnormalities, age, and gender vs. No cardiac abnormalities, younger age, male gender was evaluated on Plasma B-type natriuretic peptide (BNP) concentrations (p=<0.001). In critically ill patients, plasma BNP concentrations were significantly higher in those with cardiac abnormalities (518 vs 60 pg/mL, P<0.001), and independently increased with age and female gender.
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