March 1, 2000Cardiovascular ResearchOpen Access

Alterations in Ca2+ cycling proteins and Gαq signaling after left ventricular assist device support in failing human hearts

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Why the study?

Does left ventricular assist device support alter Ca2+ cycling proteins and Gαq signaling in patients with end-stage heart failure?

Population

7 patients with end-stage heart failure undergoing left ventricular assist device placement and subsequent…

Comparison

Left ventricular assist device (LVAD) support vs Pre-LVAD baseline (paired myocardial specimens)

Design

Cohort

Authors

YTYasuchika TakeishiHeart Failure & Transplant

Discussion

Member takes

Implication

LVAD effects on Ca2+ proteins are hypothesis-generating; prospective trials needed to link to outcomes in end-stage HF.

Structured PICO

Does left ventricular assist device support alter Ca2+ cycling proteins and Gαq signaling in patients with end-stage heart failure?

Population

7 patients with end-stage heart failure undergoing left ventricular assist device placement and subsequent heart transplantation

Intervention

Left ventricular assist device (LVAD) support

Comparator

Pre-LVAD baseline (paired myocardial specimens)

Outcome

Changes in protein levels of G alpha q, phospholipase C beta 1, regulators of G protein signaling (RGS), sarcoplasmic reticulum Ca2+ ATPase, phospholamban and translocation of protein kinase C isoforms (alpha, beta 1, and beta 2)surrogate

LVAD support in failing human hearts may improve mechanical function by increasing the expression of sarcoplasmic reticulum Ca2+ ATPase rather than reducing phospholipase C beta 1 activation.

Cite This Study

Yasuchika Takeishi (2000) studied this question.

synapsesocial.com/papers/6a1fd55d663eb9633f117cfb https://doi.org/10.1016/s0008-6363(99)00415-0

Topics

Mechanical circulatory support Heart failure HFrEF treatment

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