Key result
Nitric oxide plays a dual role in chronic pulmonary hypertension, acting as a protective vasodilator while also potentially forming cytotoxic radicals that promote adverse vascular remodeling.
Targeting the adverse effects of NO-derived radicals on vascular structure represents a potential novel therapeutic approach to pulmonary hypertension in chronic lung diseases.
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Caution advised with broad NO augmentation in chronic PH; leaves open targeted radical modulation as a research priority.
Hampl et al. (2000) conducted a review in Chronic pulmonary hypertension. Nitric Oxide was evaluated. Nitric oxide plays a dual role in chronic pulmonary hypertension, acting as a protective vasodilator while also potentially forming cytotoxic radicals that promote adverse vascular remodeling.
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