Representation of Capsaicin-evoked Urge-to-Cough in the Human Brain Using Functional Magnetic Resonance Imaging

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Key Points

To identify the neural circuitry activated during the urge-to-cough induced by capsaicin inhalation in humans.
Functional magnetic resonance imaging was used to assess brain activity in 10 healthy subjects during capsaicin inhalation.
Individualized capsaicin doses were tailored to reliably evoke a transient urge-to-cough.
BOLD measures were collected during repeated inhalation challenges, followed by urge-to-cough intensity ratings.
Capsaicin inhalation consistently evoked a significant urge-to-cough in all subjects.
Activation was observed in brain regions including the insula cortex and the anterior midcingulate cortex (p<0.05 for BOLD response).
The study provides the first evidence of a specific cortical neuronal network related to sensing airway irritation and cough modulation.

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Reveals brain regions activated during urge-to-cough from capsaicin in healthy subjects, indicating neural pathways involved.

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Mazzone et al. (2007) studied this question.

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