Key result
Sedentary animals exhibited enhanced resting splanchnic sympathetic nerve activity and mean arterial pressure, and augmented responses to RVLM activation compared to active animals.
Why the study?
Does a sedentary lifestyle increase resting and reflex-mediated splanchnic sympathetic nerve activity compared to an active lifestyle in an animal model?
Population
Animal model (active and sedentary animals housed for 10-13 weeks with or without running wheels)
Comparison
Sedentary lifestyle vs Active lifestyle
Design
Preclinical
Follow-up
10-13 weeks
Authors
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Hypothesis-generating for splanchnic sympathetic mechanisms in sedentary hypertension; human studies needed to confirm relevance.
Does a sedentary lifestyle increase resting and reflex-mediated splanchnic sympathetic nerve activity compared to an active lifestyle in an animal model?
A sedentary lifestyle augments resting and reflex-mediated sympathetic output to the splanchnic circulation and increases vascular sensitivity to adrenergic stimulation, highlighting a potential mechanism for inactivity-induced cardiovascular disease.
Mischel et al. (2011) studied Cardiovascular disease risk. Sedentary housing (without running wheels) vs. Active housing (with running wheels) was evaluated on Resting and reflex-mediated splanchnic sympathetic nerve activity (SSNA) and mean arterial pressure (MAP). Sedentary animals exhibited enhanced resting splanchnic sympathetic nerve activity and mean arterial pressure, and augmented responses to RVLM activation compared to active animals.
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