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February 13, 2020Irish Journal of Medical Science (1971 -)Open Access

Hypotension during hip fracture surgery and postoperative morbidity

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Key result

Each additional minute of intraoperative systolic arterial pressure below 80% of pre-induction baseline was associated with increased odds of progressing to a higher Clavien-Dindo complication classification (OR 1.020).

Why the study?

Intraoperative hypotension during hip fracture surgery is linked to 30-day mortality, but data correlating it with postoperative morbidity were lacking.

Is the duration and severity of intraoperative hypotension during hip fracture surgery associated with increased postoperative morbidity?

Population

52 patients undergoing hip fracture surgery

Comparison

Duration and severity of intraoperative hypotension across predefined blood pressure thresholds

Design

Retrospective analysis

Authors

GBGabriel B. BeechamRoyal College of AnaesthetistsRCRachael CusackTrinity College DublinSVSebastian VenckenUniversity College Dublin

Discussion

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Implication

Intraoperative hypotension duration was associated with greater morbidity after hip fracture surgery; leaves open whether blood pressure targets improve outcomes in trials.

Study Design

Type

Cohort (n=52)

Multicenter

No

Structured PICO

Is the duration and severity of intraoperative hypotension during hip fracture surgery associated with increased postoperative morbidity?

P
Population
52 elderly patients (mean age 78 years, 75% female) undergoing hip fracture surgery, evaluated for postoperative morbidity over 30 days.
E
Exposure
Cumulative duration of intraoperative hypotension (defined by various thresholds including SAP < 80% pre-induction baseline, MAP < 75 mmHg, MAP < 55 mmHg, SAP < 80% admission baseline)
O
Outcome
Postoperative morbidity during the first 30 postoperative days quantified by the Clavien-Dindo classification and Comprehensive Complication Indexcomposite

Main Result

Odds Ratio: 1.02 (95% CI 1.008–1.035)

p-value: p=0.003

Cumulative duration of intraoperative hypotension (SAP < 80% of pre-induction baseline) during hip fracture surgery is significantly associated with increased postoperative morbidity.

Limitations

  • Small sample size
  • Retrospective design
  • Single-centre study
  • Dichotomisation of blood pressure variables
  • Risk of overfitting due to lack of validation on a test cohort
  • Potential underestimation of total morbidity burden due to reliance on written records
  • Quantification of postoperative morbidities limited to those identified in the written record, which may underestimate total morbidity burden (e.g., delirium)

Cite This Study

Beecham et al. (2020) conducted a cohort in Hip fracture (n=52). Cumulative duration of intraoperative hypotension (SAP < 80% pre-induction baseline) vs. Shorter duration of hypotension was evaluated on Progression to a higher Clavien-Dindo complication classification (OR 1.020, 95% CI 1.008-1.035, p=0.003). Each additional minute of intraoperative systolic arterial pressure below 80% of pre-induction baseline was associated with increased odds of progressing to a higher Clavien-Dindo complication classification (OR 1.020).

synapsesocial.com/papers/6a1fdb41ea3607bd19ae8960https://doi.org/10.1007/s11845-020-02175-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study2014 · 120 citations
  2. 2The Use of a Postoperative Morbidity Survey to Evaluate Patients with Prolonged Hospitalization After Routine, Moderate-Risk, Elective Surgery1999 · 217 citations
  3. 3The Use of a Postoperative Morbidity Survey to Evaluate Patients with Prolonged Hospitalization After Routine, Moderate-Risk, Elective Surgery1999 · 272 citations
  4. 4Hypotension, subarachnoid block and the elderly patient1996 · 125 citations
  5. 5Anaesthesia for 1131 patients undergoing proximal femoral fracture repair: a retrospective, observational study of effects on blood pressure, fluid administration and perioperative anaemia2011 · 66 citations