Key result
Oligonucleotide therapies show potential to modify pathological gene targets in musculoskeletal disorders, though clinical development challenges remain.
Why the study?
Age-related musculoskeletal disorders like sarcopenia, osteoporosis, and arthritis are common chronic conditions with an unmet clinical need for safer, more efficacious pharmacological treatments.
Oligonucleotide therapies show potential for modifying pathological gene targets in age-related musculoskeletal disorders, though clinical development challenges remain.
May inform future research on gene-targeted therapies in musculoskeletal disorders; leaves open clinical validation amid development challenges.
Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. Collectively, these conditions involve multiple tissues, including skeletal muscle, bone, articular cartilage and the synovium within the joint lining. In this review, we discuss the potential for oligonucleotide therapies to combat the unmet clinical need in musculoskeletal disorders by evaluating the successes of oligonucleotides to modify candidate pathological gene targets and cellular processes in relevant tissues and cells of the musculoskeletal system. Further, we discuss the challenges that remain for the clinical development of oligonucleotides therapies for musculoskeletal disorders and evaluate some of the current approaches to overcome these.
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Nicholson et al. (2022) conducted a review in Age-related musculoskeletal disorders (sarcopenia, osteoporosis, arthritis). Oligonucleotide therapies was evaluated. Oligonucleotide therapies show potential to modify pathological gene targets in musculoskeletal disorders, though clinical development challenges remain.
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