Key result
Intra-arterial urokinase resulted in dramatic clinical improvement in a patient with an embolic stroke despite a large CT scan hypodensity within 6 hours of symptom onset.
Why the study?
Does intra-arterial urokinase improve clinical outcomes in a patient with embolic stroke and early CT hypodensity?
Case Report (n=1)
Does intra-arterial urokinase improve clinical outcomes in a patient with embolic stroke and early CT hypodensity?
Intra-arterial thrombolysis may provide dramatic clinical improvement in some patients with embolic stroke despite early CT hypodensity.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for intra-arterial thrombolysis despite early hypodensity; randomized trials needed before any practice change.
Hypodense regions demonstrated by CT within 6 hours of the onset of stroke may reflect irreversibly damaged tissue, and some have suggested that patients with such findings should be spared the risks of thrombolytic therapy since they are unable to benefit from it. We report here a patient with a low-density area demonstrated by CT less than 6 hours after onset of symptoms who improved dramatically after successful intra-arterial thrombolysis.
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Tarr et al. (1996) conducted a case report in Embolic stroke (n=1). Intra-arterial urokinase was evaluated on Clinical improvement. Intra-arterial urokinase resulted in dramatic clinical improvement in a patient with an embolic stroke despite a large CT scan hypodensity within 6 hours of symptom onset.
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