Key result
Heart-specific expression of constitutively active FoxO3 in adult mice resulted in a 25% decrease in heart weight and reversible cardiac atrophy.
Constitutively active FoxO3 induces reversible cardiac atrophy and autophagy in adult mice, demonstrating significant myocardial plasticity.
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Highlights myocardial plasticity in adult mice; leaves open FoxO3 targeting in human cardiac remodeling.
Schips et al. (2011) studied Cardiac atrophy. Constitutively active FoxO3 transgene (FoxO3-CA) expression was evaluated on Heart weight. Heart-specific expression of constitutively active FoxO3 in adult mice resulted in a 25% decrease in heart weight and reversible cardiac atrophy.
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