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August 12, 2025

FoxO3 Activation Alleviates Doxorubicin-Induced Cardiomyopathy by Enhancing Autophagic Flux and Suppressing mTOR/ROS Signalling.

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Authors

ZCZaoshang ChangLWLe WangJZJu-Xiang Zhou

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Overview

Experimental analysis shows FoxO3 enhances autophagy and reduces ROS in doxorubicin-induced cardiomyopathy models, indicating potential therapeutic strategies.

Key Points

  • FoxO3 activation significantly alleviates doxorubicin-induced cardiomyopathy by enhancing protective autophagy, reducing cardiac damage and dysfunction.
  • Key findings show that overexpressing FoxO3 enhances autophagic flux and decreases levels of oxidative stress markers like ROS and MDA.
  • The approach involved in vivo and in vitro models, assessing the impact of FoxO3 on cardiac cell viability through autophagy mechanisms.
  • These findings support targeting FoxO3 activation as a promising strategy for mitigating doxorubicin-associated cardiac toxicity.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/68a360f20a429f7973329afdhttps://doi.org/10.1111/jcmm.70775
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