Key result
PTCA injury in humans resulted in upregulation of ACE at sites of active repair within 2 months, which decreased by 3 months and was no longer expressed from 7 months on.
Observational (n=37)
ACE is upregulated at sites of active repair following PTCA in humans, suggesting a potential role in the healing process.
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Transient ACE upregulation post-PTCA supports timed inhibition trials; should not yet change practice.
Ohishi et al. (1997) conducted an observational in Angioplasty injury post-PTCA (n=37). Percutaneous transluminal coronary angioplasty (PTCA) injury vs. Segments without angiographic evidence of restenosis was evaluated on Presence and expression of ACE in the neointima. PTCA injury in humans resulted in upregulation of ACE at sites of active repair within 2 months, which decreased by 3 months and was no longer expressed from 7 months on.
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