Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
Key result
Regional adiposity measures, including subcutaneous and visceral adipose tissue, were not significantly associated with circulating measures of renin-angiotensin-aldosterone system activity.
Why the study?
Is regional adiposity associated with circulating measures of RAAS activity in a community-based sample?
Population
1,889 participants from the Third Generation Framingham Heart Study, mean age 40 years, 7% hypertension, 3%…
Design
Cross-sectional
Authors
Discussion
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Implication
No association observed in this cohort does not support clinical inferences on adiposity-RAAS links; leaves open longitudinal or mechanistic studies.
Study Design
Type
Cross-Sectional (n=1,889)
Structured PICO
Is regional adiposity associated with circulating measures of RAAS activity in a community-based sample?
P
Population
1,889 community-based adults (mean age 40, 53% female) from the Framingham Heart Study underwent cross-sectional assessment to evaluate the correlation between regional adiposity and systemic RAAS activity.
O
Outcome
Correlation between systemic RAAS activity (plasma renin activity, serum aldosterone, aldosterone:renin ratio) and regional adiposity measures (subcutaneous and visceral adipose tissue volumes)surrogate
Main Result
Effect estimate: r = 0.04
p-value: p=0.1
Regional adiposity measures (SAT and VAT) are not associated with circulating measures of RAAS activity in a large, community-based cohort.
Limitations
- Cross-sectional design cannot capture dynamic changes in RAAS components due to active weight gain.
- Ambulatory RAAS measurements were drawn from individuals on a free-living sodium diet while taking usual antihypertensive medications.
- Absence of data on sodium intake and urinary excretion.
- Blood samples were drawn after only 10 minutes in the supine position rather than 1 hour.
- Inability to directly measure markers of local RAAS activation in adipose tissue.
- Sample was primarily white and middle-aged, limiting generalizability to other racial/ethnic or age groups.
Cite This Study
O’Seaghdha et al. (2012) conducted a cross-sectional in Obesity and Hypertension Risk (n=1,889). Regional adiposity (subcutaneous and visceral adipose tissue) was evaluated on Correlation between subcutaneous adipose tissue (SAT) volume and log-transformed plasma renin activity (r = 0.04, p=0.1). Regional adiposity measures, including subcutaneous and visceral adipose tissue, were not significantly associated with circulating measures of renin-angiotensin-aldosterone system activity.