Why the study?
Which technique is most sensitive for detecting antiplatelet antibodies in patients with autoimmune thrombocytopenic purpura?
Which technique is most sensitive for detecting antiplatelet antibodies in patients with autoimmune thrombocytopenic purpura?
Platelet factor 3 availability and immunoperoxidase techniques offer higher sensitivity than 14C-5HT release for detecting antiplatelet antibodies in ATP.
May aid antiplatelet antibody detection in ATP; leaves open prospective validation of clinical utility.
An evaluation of three techniques for detection of antiplatelet antibodies in ATP is made. The platelet factor 3 availability after immunoinjury and the immunohystochemical technique using immunoperoxidase were more sensitive than 14C-5HT release from platelets for this purpose. The percentage of positive cases was similar in acute and chronic ATP patients while it significantly fell in cases in remission. A high proportion of patients in clinical remission had normal platelet aggregation, despite the persistence of antiplatelet antibodies.
No takes yet. Share an insight, caveat, or question.
Vizcaíno et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: