What question did this study set out to answer?

The study aims to characterize the physical, chemical, and ultrastructural properties of amyloid fibrils from patients with amyloidosis.

Physical, Chemical, and Ultrastructural Studies of Water-Soluble Human Amyloid Fibrils

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial evaluates structural variations of amyloid fibrils in amyloidosis, indicating unique characteristics across individuals.

The study aims to characterize the physical, chemical, and ultrastructural properties of amyloid fibrils from patients with amyloidosis.
Amyloid fibrils were isolated from nine patients using tissue homogenization and distilled water extraction.
Morphological analysis was conducted through negative staining and sedimentation studies.
Chemical methods, including sodium hydroxide treatment, were investigated for producing smaller subunits.
Isolated fibrils exhibited morphologic variations, with three distinct types identified.
Most preparations sedimented at 45-50S, but some showed 8-9S sedimentation coefficients.
Chemical analysis estimated a subunit molecular weight of approximately 35,000-40,000 after sodium hydroxide treatment.

Pras et al. (1969) studied this question.

View Full Paper

Ask AI

Bookmark