Key result
Trisomy 13 pregnancies are associated with placental abnormalities and preeclampsia, potentially linked to candidate genes on chromosome 13 such as sFlt1, COL4A2, and periostin.
This review highlights the association between trisomy 13 pregnancies and the development of placental abnormalities and preeclampsia, pointing to specific candidate genes on chromosome 13.
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Should not alter clinical management of trisomy 13 pregnancies; hypothesis-generating for chromosome 13 gene-targeted preeclampsia research.
Women who are carrying a trisomy 13 fetus are prone to have an abnormal placenta as well as to develop preeclampsia in the second and third trimesters. This article provides a comprehensive review of placental abnormalities, such as small placental volume, reduced placental vascularization, a partial molar appearance of the placenta and placental mesenchymal dysplasia, and preeclampsia associated with trisomy 13 pregnancies. The candidate preeclampsia-causing genes on chromosome 13, such as sFlt1, COL4A2 and periostin, are discussed.
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Chih‐Ping Chen (2009) conducted a review in Trisomy 13 pregnancies, placental abnormalities, and preeclampsia. Trisomy 13 pregnancy was evaluated on Placental abnormalities and preeclampsia. Trisomy 13 pregnancies are associated with placental abnormalities and preeclampsia, potentially linked to candidate genes on chromosome 13 such as sFlt1, COL4A2, and periostin.
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