Key result
A 6-month supervised combined resistance and aerobic exercise program significantly improved VO2 peak (35.7 vs 41.7 mL/min/kg, P=0.05) and HOMA-IR (3.65 vs 2.72, P=0.02) in childhood HSCT/TBI survivors.
Why the study?
To investigate the effects of a supervised combined resistance and aerobic training programme on cardiorespiratory fitness, body composition, insulin resistance, and quality of life in survivors of childhood HSCT with total body irradiation.
Does a supervised combined resistance and aerobic training programme improve cardiorespiratory fitness, body composition, insulin resistance, and quality of life in survivors of childhood HSCT with TBI?
Does a supervised combined resistance and aerobic training programme improve cardiorespiratory fitness, body composition, insulin resistance, and quality of life in survivors of childhood HSCT with TBI?
Absolute Event Rate: 41.7% vs 35.7%
p-value: p=0.05
A 6-month supervised combined resistance and aerobic exercise program significantly improved cardiorespiratory fitness, insulin resistance, and quality of life in childhood HSCT/TBI survivors, supporting targeted physical rehabilitation in this high-risk group.
May support supervised exercise in HSCT survivors; leaves open confirmation in randomized trials.
Purpose To investigate the effects of a supervised combined resistance and aerobic training programme on cardiorespiratory fitness, body composition, insulin resistance and quality of life (QoL) in survivors of childhood haematopoietic stem cell transplantation (HSCT) with total body irradiation (TBI). Participants HSCT/TBI survivors ( n = 20; 8 females). Mean (range) for age at study and time since HSCT/TBI was 16.7 (10.9‐24.5) and 8.4 (2.3‐16.0) years, respectively. Methods After a 6‐month run‐in, participants undertook supervised 45‐ to 60‐minute resistance and aerobic training twice weekly for 6 months, with a 6‐month follow‐up. The following assessments were made at 0, 6 (start of exercise programme), 12 (end of exercise programme) and 18 months: Body composition via dual energy X‐ray absorptiometry, homeostatic model assessment of insulin resistance (HOMA‐IR), cardiorespiratory fitness (treadmill‐based peak rate of oxygen uptake (VO 2 peak) test), QoL questionnaires (36‐Item Short Form Health Survey (SF‐36) and Minneapolis‐Manchester Quality of Life Instrument (MMQL). Results Results expressed as mean (standard deviation) or geometric mean (range). There were significant improvements in VO 2 peak (35.7 (8.9) vs 41.7 (16.1) mL/min/kg, P = 0.05), fasted plasma insulin (16.56 (1.48‐72.8) vs 12.62 (1.04‐54.97) mIU/L, P = 0.03) and HOMA‐IR (3.65 (0.30‐17.26) vs 2.72 (0.22‐12.89), P = 0.02) after the exercise intervention. There were also significant improvements in the SF‐36 QoL general health domain (69.7 (14.3) vs 72.7 (16.0), P = 0.001) and the MMQL school domain (69.1 (25.2) vs (79.3 (21.6), P = 0.03) during the exercise intervention. No significant changes were observed in percentage body fat, fat mass or lean mass. Conclusion The supervised 6‐month combined resistance and aerobic exercise programme significantly improved cardiorespiratory fitness, insulin resistance and QoL in childhood HSCT/TBI survivors, with no change in body composition, suggesting a metabolic training effect on muscle. These data support a role for targeted physical rehabilitation services in this group at high risk of diabetes and cardiovascular disease.
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Davis et al. (2020) studied Childhood haematopoietic stem cell transplantation (HSCT) with total body irradiation (TBI) (n=20). Supervised combined resistance and aerobic training programme was evaluated on Cardiorespiratory fitness (VO2 peak) (p=0.05). A 6-month supervised combined resistance and aerobic exercise program significantly improved VO2 peak (35.7 vs 41.7 mL/min/kg, P=0.05) and HOMA-IR (3.65 vs 2.72, P=0.02) in childhood HSCT/TBI survivors.
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