January 1, 2021Open Access

Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries

ATAndré A. TeixeiraNew Mexico Consortium MEM. Frank ErasmusIQVIA (United Kingdom)SDSara D’AngeloIQVIA (United Kingdom)

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Abstract

AC-SINS: affinity-capture self-interaction nanoparticle spectroscopy; CDR: complementarity-determining region; CQA: critical quality attribute; ELISA: enzyme-linked immunoassay; FACS: fluorescence-activated cell sorting; Fv: fragment variable; GM-CSF: granulocyte-macrophage colony-stimulating factor; HCDR3: heavy chain CDR3; IFN2a: interferon α-2; IL6: interleukin-6; MACS: magnetic-activated cell sorting; NGS: next generation sequencing; PCR: polymerase chain reaction; SEC: size-exclusion chromatography; SPR: surface plasmon resonance; TGFβ-R2: transforming growth factor β-R2; VH: variable heavy; VK: variable kappa; VL: variable light; Vl: variable lambda.

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Teixeira et al. (Fri,) studied this question.

synapsesocial.com/papers/6a1fe7df75fc4a116b2e48ed https://doi.org/https://doi.org/10.1080/19420862.2021.1980942

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