Key result
Animal models, including rodents, rabbits, and pigs, are essential for investigating the pathophysiology of cardiac arrest and evaluating new therapeutic approaches for cardiopulmonary resuscitation.
The choice of animal species and method of cardiac arrest induction is crucial for resuscitation research due to significant anatomical and physiological differences compared to humans.
Animal research is essential to propose new therapeutic approaches limiting the sequels of cardiac arrest in human and veterinary medicine. The ultimate goal is to improve the long term prognosis and neurological recovery. For such investigations, the use of animal models seems unavoidable as cardiac arrest provokes multiple visceral consequences as well as inflammatory response and coagulopathy. These models allow not only a better understanding of the pathophysiology but also the investigation of new treatment strategies to improve basic life support efficiency or prevent multi-organ failure. In this review, we are summarizing the characteristics of the main animal models used in resuscitation sciences. The choice of the species and methods of evaluation of cardiac arrest is crucial. These studies often concern human medicine but they can also address fundamental questions for veterinary research as they are mostly based on animal research.
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Renaud Tissier (2016) conducted a review in Cardiac arrest. Animal models of cardiac arrest was evaluated. Animal models, including rodents, rabbits, and pigs, are essential for investigating the pathophysiology of cardiac arrest and evaluating new therapeutic approaches for cardiopulmonary resuscitation.
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