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January 2, 2017Eurasian Journal of Emergency MedicineOpen Access

The Diagnostic Value of SCUBE1 in Unstable Angina Pectoris Patients

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Key result

SCUBE1 levels did not significantly differ between patients with USAP, NSTEMI, STEMI, non-cardiac chest pain, and healthy controls (p=0.650), indicating it is not diagnostic for these conditions.

Why the study?

Does SCUBE1 measurement distinguish patients with unstable angina pectoris from those with NSTEMI and non-cardiac chest pain?

Population

230 individuals, comprising 185 patients presenting with chest pain or suspected acute coronary syndrome and…

Comparison

SCUBE1 biomarker measurement vs Routine laboratory parameters and comparison…

Design

Cross-sectional

Authors

AÖAbuzer ÖzkanESErtan SönmezSÖSerdar Özdemir

Discussion

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Overview

SCUBE1 should not guide ACS diagnosis in chest pain; leaves open the need for validated biomarkers in prospective studies.

Study Design

Type

Observational (n=230)

Structured PICO

Does SCUBE1 measurement distinguish patients with unstable angina pectoris from those with NSTEMI and non-cardiac chest pain?

P
Population
230 participants, including 185 patients presenting with chest pain or suspected acute coronary syndrome (USAP, NSTEMI, STEMI, or NCCP) and 45 healthy controls.
E
Exposure
SCUBE1 biomarker measurement
C
Comparator
Routine laboratory parameters (Troponin I) and comparison across clinical groups
O
Outcome
Diagnostic value of SCUBE1 in distinguishing unstable angina pectoris from NSTEMI and non-cardiac chest painsurrogate

Main Result

p-value: p=0.650

SCUBE1 is not a useful diagnostic biomarker for distinguishing unstable angina pectoris, NSTEMI, and STEMI from non-cardiac chest pain.

Cite This Study

Özkan et al. (2017) conducted an observational in Acute coronary syndrome / Chest pain (n=230). SCUBE1 biomarker vs. Healthy controls was evaluated on Difference in SCUBE1 levels between patient groups and healthy controls (p=0.650). SCUBE1 levels did not significantly differ between patients with USAP, NSTEMI, STEMI, non-cardiac chest pain, and healthy controls (p=0.650), indicating it is not diagnostic for these conditions.

synapsesocial.com/papers/6a1fe9951517a826fb04aaa5https://doi.org/10.5152/eajem.2016.83997
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