Key result
Patients with HIV-associated adipose redistribution syndrome exhibited increased interstitial noradrenaline in skeletal muscle and subcutaneous adipose tissue without changes in global sympathetic activity.
Observational
Locally increased sympathetic activity in skeletal muscle and subcutaneous adipose tissue may promote localized lipolysis and contribute to the development of HARS in patients with HIV-1.
It was recently suggested that HIV-associated adipose redistribution syndrome (HARS) results from an autonomic dysbalance. We investigated the local and global sympathetic nervous system function of patients with HIV-1 infection and HARS. Interstitial noradrenaline concentrations in skeletal muscle and subcutaneous adipose tissue were increased in the absence of changes in global sympathetic nerve activity, consistent with locally increased sympathetic activity. This could promote localized lipolysis in subcutaneous adipose tissue and contribute to the development of HARS.
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Gurp et al. (2006) conducted an observational in HIV-1 infection and HIV-associated adipose redistribution syndrome (HARS). HIV-associated adipose redistribution syndrome (HARS) was evaluated on Interstitial noradrenaline concentrations in skeletal muscle and subcutaneous adipose tissue and global sympathetic nerve activity. Patients with HIV-associated adipose redistribution syndrome exhibited increased interstitial noradrenaline in skeletal muscle and subcutaneous adipose tissue without changes in global sympathetic activity.
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