Ertapenem Associated with Generalized Tonic-Clonic Seizure in a Patient with Chronic Kidney Disease

Seizures have been associated with meropenem and imipenem, but ertapenem induced seizure was scarce. Here we describe one patient with chronic kidney disease developed seizure after treating with ertapenem for five doses and reviewed previous reports in the English literature. The abnormalities of center nervous system (CNS) and renal function were the most common underlying diseases among these patients. In conclusion, ertapenem should be considered as one of possible etiologies of seizure during its administration, especially in elder patients with CNS disorder or renal insufficiency.