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May 1, 1992Journal of Clinical InvestigationOpen Access

Evidence for an additional intracellular site of action of probucol in the prevention of oxidative modification of low density lipoprotein. Use of a new water-soluble probucol derivative.

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SPS ParthasarathyChandigarh University

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S Parthasarathy (1992) studied this question.

synapsesocial.com/papers/6a1fea638fbc0747110da128https://doi.org/10.1172/jci115757
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.1984 · 1,637 citations
  2. 2Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.1987 · 1,040 citations
  3. 3Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages1991 · 220 citations
  4. 4Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.1990 · 427 citations
  5. 5Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits.1989 · 24 citations