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The author conducted a study of 25 retarded depressed patients who previously responded inadequately to tricyclic antidepressants. Continuing the group on antidepressants, he also administered thyroid hormone. Fourteen showed an excellent response to the combination. He concludes that thyroid hormone potentiates the effects of the tricyclic antidepressants to some extent, but he suggests the need for further study in this area.
BRIAN V. EARLE (1970) studied this question.