Why the study?
Beta-blockers are being investigated for angiosarcoma, but because most patients lack cardiovascular co-morbidity, identifying the optimal pharmacological properties to balance efficacy and cardiovascular adverse events is crucial.
Which beta-blocker offers the optimal pharmacological profile to maximize anti-tumor efficacy while minimizing cardiovascular adverse events in patients with angiosarcoma?
Which beta-blocker offers the optimal pharmacological profile to maximize anti-tumor efficacy while minimizing cardiovascular adverse events in patients with angiosarcoma?
While propranolol is currently used in angiosarcoma trials, non-selective beta-blockers with intrinsic sympathomimetic activity or vasodilator effects (labetalol, pindolol, carvedilol) should be considered in future studies to reduce cardiovascular adverse events.
Non-selective beta-blockers with ISA or vasodilatory effects may limit bradycardia in angiosarcoma; leaves open optimal agent selection for trials.
Beta-blockers are currently studied to improve therapeutic options for patients with angiosarcoma. However, most of these patients have no cardiovascular co-morbidity and it is therefore crucial to discuss the most optimal pharmacological properties of beta-blockers for this population. To maximize the possible effectiveness in angiosarcoma, the use of a non-selective beta-blocker is preferred based on in vitro data. To minimize the risk of cardiovascular adverse events a beta-blocker should ideally have intrinsic sympathomimetic activity or vasodilator effects, e.g. labetalol, pindolol or carvedilol. However, except for one case of carvedilol, only efficacy data of propranolol is available. In potential follow-up studies labetalol, pindolol or carvedilol can be considered to reduce the risk of cardiovascular adverse events.
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Embaby et al. (2022) studied this question.
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