What question did this study set out to answer?

The study aims to investigate the relationship between QRS complex width and the anatomical pathology of the cardiac conduction system in patients with chronic complete atrioventricular block.

April 1, 1981CirculationOpen Access

Correlation of the width of the QRS complex with the pathologic anatomy of the cardiac conduction system in patients with chronic complete atrioventricular block.

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Why the study?

How does the width of the QRS complex correlate with the pathologic anatomy of the cardiac conduction system in patients with chronic complete AV block?

Population

27 cases, including 14 with chronic complete atrioventricular block and 13 without chronic complete AV block.

Comparison

Histological examination of the atrioventricular… vs Comparison between patients with narrow versus…

Design

Cross-sectional

Authors

SOShin-ichiro OhkawaTokyo Medical and Dental University DHDonald B. HackelUniversity of Southern California RIR.E. IdekerU.S. National Science Foundation

Discussion

Member takes

Implication

Informs QRS morphology in chronic AV block; extends anatomic correlations but leaves open prospective validation.

Key Points

The study aims to investigate the relationship between QRS complex width and the anatomical pathology of the cardiac conduction system in patients with chronic complete atrioventricular block.
Analyzed electrocardiographic findings and histology in 14 patients with chronic complete AV block and 13 controls.
Divided patients into two groups based on QRS width (narrow vs wide) for comparison.
Identified lesions in the His bundle and surrounding structures through histological examination.
In group 1 (narrow QRS), lesions were primarily in the His bundle, with 75% having idiopathic fibrosis.
In group 2 (wide QRS), lesions were more extensive, often involving bilateral bundle branches with idiopathic causes in all but one case.
In control cases, the conduction system appeared normal with minimal aging changes.

Structured PICO

How does the width of the QRS complex correlate with the pathologic anatomy of the cardiac conduction system in patients with chronic complete AV block?

Population

27 cases, including 14 with chronic complete atrioventricular (AV) block and 13 without chronic complete AV block.

Intervention

Histological examination of the atrioventricular conduction system.

Comparator

Comparison between patients with narrow (<0.12 second) versus wide (≥0.12 second) QRS complexes, and versus patients without AV block.

Outcome

Correlation of QRS complex width with the pathologic anatomy of the cardiac conduction system.surrogate

The study demonstrates that complete AV block with either narrow or wide QRS complexes can result from lesions in the branching portion of the His bundle, depending on lesion severity and involvement of adjacent bundle branches.

Cite This Study

Ohkawa et al. (1981) studied this question.

synapsesocial.com/papers/6a1febdd8fbc0747110da350 https://doi.org/10.1161/01.cir.63.4.938

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Correlation of the width of the QRS complex with the pathologic anatomy of the cardiac conduction system in patients with chronic complete atrioventricular block.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Correlation of the width of the QRS complex with the pathologic anatomy of the cardiac conduction system in patients with chronic complete atrioventricular block.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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