February 12, 2021MedicineOpen Access

Association of uncoupling protein-2 -866G/A and Ala55Val polymorphisms with susceptibility to type 2 diabetes mellitus

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Why the study?

Studies evaluating relationships between UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes mellitus risk have reported inconsistent results.

Are UCP2 -866G/A and Ala55Val polymorphisms associated with an increased risk of type 2 diabetes mellitus?

Structured PICO

Are UCP2 -866G/A and Ala55Val polymorphisms associated with an increased risk of type 2 diabetes mellitus?

Population

26 studies assessing the relationship between UCP2 rs659366 and rs660339 polymorphisms and the risk of type 2 diabetes mellitus

Intervention

Presence of UCP2 -866G/A (rs659366) and Ala55Val (rs660339) polymorphisms

Comparator

Absence of these polymorphisms (wild-type alleles)

Outcome

Risk of type 2 diabetes mellitus (T2DM)hard clinical

The UCP2 rs659366 polymorphism is associated with an increased susceptibility to type 2 diabetes mellitus, particularly in Asian populations.

Implication

Supports UCP2 rs659366 as T2DM risk marker in Asians; extends genetic association meta-analyses.

Abstract

BACKGROUND: Recently, the relationships between uncoupling protein-2 (UCP2) -866G/A (rs659366) and Ala55Val (rs660339) polymorphisms and the risk of type 2 diabetes mellitus (T2DM) have been explored considerably, but the results are greatly inconsistent. This meta-analysis was performed to further identify the association of UCP2 rs659366 and rs660339 with the risk of T2DM. METHODS: Eligible studies were searched from PubMed, Embase, Cochrane Library, VIP database, Chinese National Knowledge Infrastructure, and Chinese WanFang database until March 8, 2020. The odds ratios with corresponding 95% confidence intervals (CIs), and P-values were used to assess the strength of the association. RESULTS: A total of 26 studies were included in this study. UCP2 rs659366 was associated with the risk of T2DM in allele model (OR: 1.112, 95%CI: 1.009-1.224, P = 0.032), dominant model (OR: 1.189, 95%CI: 1.035-1.366, P = 0.014), and heterozygous model (OR: 1.177, 95%CI: 1.032-1.342, P = .015). A significantly increased risk of T2DM was detected in Asians by UCP2 rs659366 allele (OR: 1.132, 95%CI: 1.016-1.262, P = .025), dominant (OR: 1.218, 95%CI: 1.046-1.418, P = .011), homozygous (OR: 1.254, 95%CI: 1.022-1.540, P = .031) or heterozygous (OR: 1.198, 95%CI: 1.047-1.371, P = .009) models. There was no significant correlation between UCP2 rs660339 and the risk of T2DM (P>.05). CONCLUSIONS: The UCP2 rs65366 is significantly associated with the risk of T2DM, especially in Asian population, while no evidence is found between the UCP2 rs660339 and the susceptibility to T2DM.