Key result
Depicting physiological homeostasis using a self-coupled system (SCS) allows homeostatic dynamics to be expressed by simple mathematical language and reveals a new disease group.
Why the study?
The negative feedback system has been regarded as the basic unit of regulation of physiological homeostasis, but its depiction possesses limitations.
The self-coupled system offers a novel mathematical approach to depicting physiological homeostasis, supplementing traditional negative feedback system models.
The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics can be expressed by simple mathematical language. A new disease group was revealed and some useful inferences were obtained through mathematical deduction. They were supported by published studies. SCS-based depiction of homeostasis should be a requisite supplement to medical knowledge systems based on NFS.
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Lu et al. (2019) studied Physiological homeostasis. Self-coupled system (SCS) depiction vs. Negative feedback system (NFS) depiction was evaluated. Depicting physiological homeostasis using a self-coupled system (SCS) allows homeostatic dynamics to be expressed by simple mathematical language and reveals a new disease group.
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